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Michael W Deem

Michael W Deem currently holds the position of General Partner at SmartHealth Catalyzer and steers a burgeoning startup as its CEO. His prior tenure as an Entrepreneur in Residence at Khosla Ventures saw him evaluating potential portfolio companies, fostering startup incubation, and providing guidance to existing portfolio ventures. His main focus areas were life sciences and sustainability. As an accomplished American engineer, scientist, and innovator, Michael’s career is marked by notable achievements and contributions.

From 2002 to 2020, Dr. Deem’s academic journey was intertwined with Rice University. He distinguished himself as the John W. Cox Professor of Bioengineering and Physics & Astronomy. Between 2014 and 2017, he led the Bioengineering Department as its chair and was instrumental in establishing the Graduate Program in Systems, Synthetic, and Physical Biology, a pioneering PhD program in the U.S. that prominently featured ‘Synthetic Biology’ in its nomenclature.

The breadth of Michael’s expertise encompasses life sciences and nanoporous materials. His research group at Rice University has been at the forefront of numerous breakthroughs. His areas of specialization include but are not limited to synthetic biology, evolutionary science, vaccine development, statistical mechanics, and zeolites.

Michael’s academic roots trace back to his roles as an assistant and associate professor at UCLA from 1996 to 2002. His academic foundation was laid at the California Institute of Technology where he earned his BS, followed by a PhD from UC Berkeley, and a postdoctoral fellowship at Harvard University.

In the professional realm, Michael’s experience is vast and diverse. He has held influential positions in senior management, on Boards, and as an advisor, imparting his extensive knowledge across various industries. His contributions have significantly advanced fields such as life sciences, artificial intelligence, genomics, data science, biotechnology, energy, and cancer research.

Dr. Deem’s scholarly output is substantial, with over 200 published papers and more than 300 invited talks to his name. His innovative prowess is evidenced by his 16 U.S. patents. As a professor at both Rice University and UCLA, he has mentored a multitude of students and imparted knowledge to over 10,000 undergraduates.

His contributions to the fields of bioengineering, physics, and chemical engineering are profound and multifaceted. He is the mind behind DIFFAX and ZEFSA, essential tools in materials science, and the creator of a comprehensive predicted zeolite structures database. His inventions and theories in protein molecular evolution, vaccine effectiveness characterization, and biological evolution are groundbreaking. His insights into environmental pressures, genetic exchange, and immune system evasion mechanisms have reshaped scientific understanding in these areas. His advancements in Monte Carlo simulation methods further underscore his status as a pioneering innovator, a recognition solidified by numerous awards.

Outside the professional sphere, Michael embraces the joys of life with zeal. He is an avid rock climber, an enthusiast of high-performance cars, and a dedicated practitioner of Taekwondo, reflecting his passion for both adventure and discipline.

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Michael Deem


Michael Deem is currently a General Partner with SmartHealth Catalyzer and CEO of a startup. He was previously an Entrepreneur in Residence at Khosla Ventures. At Khosla, Michael was responsible for reviewing companies for portfolio inclusion, incubating startups, and mentoring portfolio companies. He worked in the life science and sustainability areas. Michael is an American engineer, scientist, and inventor.

Dr. Deem was with Rice University from 2002-2020. At Rice, he was the John W. Cox Professor of Bioengineering and Physics & Astronomy. He was chair of the Bioengineering Department from 2014 to 2017. He was the founding director of the Graduate Program in Systems, Synthetic, and Physical Biology. This was the first PhD program in the US with ‘Synthetic Biology’ in the title.

Michael’s expertise lies in the life sciences and nanoporous materials. The Michael Deem Rice University group made many contributions. Among Michael’s fields of specialization are synthetic biology, evolution, vaccines, statistical mechanics, and zeolites.

Michael was an assistant and associate professor at UCLA, 1996-2002. He received his BS from the California Institute of Technology, PhD from UC Berkeley. He received a postdoctoral fellowship from Harvard University.

Michael is an experienced senior professional. He has operated in senior management, board and advisory capacities. His intellectual bandwidth has benefited companies from a wide cross section of industries. He has advanced life sciences, artificial intelligence, genomics, data science, biotechnology, energy, and cancer research.

Dr. Deem has published over 200 papers. He has given over 300 invited talks. He is listed as an inventor on 16 US patents. Michael W. Deem Rice University and UCLA professor has mentored hundreds of students and taught over 10,000 undergraduates.

Michael has made significant contributions to bioengineering, physics, and chemical engineering. He developed the widely used tools DIFFAX and ZEFSA for materials science. He created the widely used database of predicted zeolite structures. He invented the hierarchical approach to protein molecular evolution. He developed the pEpitope method to characterize vaccine effectiveness and antigenic distance for influenza. He developed the theory of modularity for biological evolution. He showed that changing environmental pressures lead to the spontaneous emergence of modularity in biological systems. He showed the importance of cross-species genetic exchange for rapid evolution. He developed the polytopic vaccination method for sculpting the immune response to multi-strain pathogens. He created a theory of the competition for access to antigen that allows HIV to escape recognition by the immune system. He has made major contributions to Monte Carlo simulation methods. He is widely recognized as an innovator. For these contributions, among others, Mike Deem received numerous awards.

Michael enjoys life, work, and play. He is an avid rock climber. He enjoys high-performance cars. And he is a long-time Taekwondo practitioner.